鄭世榮醫師詳細介紹

在口腔腫瘤的基礎研究上，發現PAX1與ZNF582兩個抑癌基因的甲基化，可當成口腔黏膜疾病及口腔癌早期篩檢的重要生物標記，並與口腔癌復發或存活時間有相關性。於此領域已發表多篇論文，且為口腔癌早期篩檢的重要發現。另外發現新的口腔癌致病機轉，由檳榔鹼誘導EV(外泌體)攜帶 mtDNA D-loop和PD-L1，並引起免疫抑制。然而，利用微生物衍生的生物反應調控劑（biological response modifier, BRM），由酵母菌萃取之WGP ß-glucan為一具有ß-1,3-linked D-glucose molecules骨架結構之分子，在臨床上已知有免疫調節之作用，可強化免疫功能，並活化 CD4/8 T 細胞，抑制Treg cell和促進細胞凋亡，有利於 OSCC病人輔助標靶和免疫療法之使用。此研究發現已於台大醫院營養室列為常規輔助食品，頭頸癌病人等待手術時給予，為重要的輔助治療。最難能可貴是研究以迷你植體，應用於治療咬合不正之患者，此研究結果發表於IJOMI，被引用430次。

• Ko HH, Wu FY, Chen YS, Lin Wender, Fang CK, Bai CH, Lin HY, Kao HF, Cheng SJ. Sex differences in prognostic factors and genomic variations in oral squamous cell carcinoma: A 5-year retrospective study. J Dent Sci. accepted, 2025.
• Ko HH, Peng HH, Chou HYE, Hou HH, Liu WW, Kuo MYP, Lee AYL, Kao HF, Lin HY, Chang YC, Kuo WT, Cheng SJ. Downregulation of PAX1 in OSCC enhances stemness and immunosuppression via IFIT1 and PD-L1 pathways. Oral Dis. 2024 accepted for publication.
• Wei LY, Cheng YW, Chiu WY, Kok SH, Chang HH, Cheng SJ, Lee JJ. Risk Factors Influencing Medication-Related Osteonecrosis of the Jaws (MRONJ) Following Dental Extraction Among Osteoporotic Patients in Taiwan. Head Neck. 2024 Nov 29.
• Chen TC, Liu WC, Cheng SJ, Lin SP, Lin W. Trends of dental service utilization and expenditure in Taiwan from 2000 to 2020. J Dent Sci. 2024 Nov.
• Hsu MS, Yeh CL, Cheng SJ, Lin CP. Integrating digital technologies in dental technician education: A comparative study of national examination in Asian countries. J Dent Sci. 2024 Nov.
• Chen YW, He AC, Huang TY, Lai DH, Wang YP, Liu WW, Kuo WT, Hou HH, Cheng SJ, Lee CY, Chuang WC, Chang CC, Lee BS. Iontophoresis-Enhanced Buccal Delivery of Cisplatin-Encapsulated Chitosan Nanoparticles for Treating Oral Cancer in a Mouse Model. Int J Nanomedicine. 2024 Oct 16;19:10435-10453.
• Ko HH, Chou HYE, Hou HH, Kuo MYP, Cheng SJ. Oleanolic acid inhibits aldo-keto reductase family 1member B10-induced cancer stemness and avoids cisplatin-based chemotherapy resistance via the Snail signaling pathway in oral squamous cell carcinoma cell lines. J Dent Sci. 2024 Oct.
• Wang HW, Yang CN, Kok SH, Hong CY, Shun CT, Lai EH, Cheng SJ, Lin HY, Wu FY, Lin SK. 27-Hydroxycholesterol contributes to hypercholesterolemia-associated aggravation of apical periodontitis in ovariectomized rats and raloxifene counteracts its action. Int Endod J. 2024 Sep 10.
• Ko HH, Chou CH, Cheng SJ. The dental implant survival rate in 18 patients with post-operation revolutionary jaw reconstruction using free fibular flap, dental implants, and overdentures. J Dent Sci. 2024 Jul;19(3):1819-1826.
• Chen YW, Hou YW, Wang CW, Cheng SJ, Kuo WT, Lin CP, Hou HH. Oral Lactobacillus zeae exacerbates the pathological manifestation of periodontitis in a mouse model. Mol Oral Microbiol. 2024 Oct;39(5):344-353.
• Chung YY, Cheng SJ, Ko HH, Shie WY, Elizabeth Chou HY. Evaluation of the prognostic and therapeutic potential of inhibin beta B for oral squamous cell carcinoma. J Dent Sci. 2024 Jan;19(1):448-454. doi: 10.1016/j.jds.2023.07.014.
• Lai CJ, Shih PY, Cheng YJ, Lin CK, Cheng SJ, Peng HH, Chang WT, Chien KL. Incidence and risk factors of postoperative pulmonary complications after oral cancer surgery with free flap reconstruction: A single center study. J Formos Med Assoc. 2024 Mar;123(3):347-356.
• Cheng SJ, Shie WY, Chen KC, Tang CC, Peng HH, Ko HH, Hou HH, Elizabeth Chou HY. Fibroblast growth factor 5 expression predicts the progression of oral squamous cell carcinoma. J Formos Med Assoc. 2024 Mar;123(3):390-399.
• Lin SK, Wang HW, Shun CT, Yang CN, Hong CY, Lai EH, Cheng SJ, Chen MH, Yang H, Lin HY, Wu FY, Kok SH. Sirtuin 6 ameliorates arthritis through modulating cyclic AMP-responsive element binding protein/CCN1/cyclooxygenase 2 pathway in osteoblasts. J Bone Miner Metab. 2023 Nov;41(6):772-784.
• Hong CY, Lin SK, Wang HW, Shun CT, Yang CN, Lai EH, Cheng SJ, Chen MH, Yang H, Lin HY, Wu FY, Kok SH. Metformin Reduces Bone Resorption in Apical Periodontitis Through Regulation of Osteoblast and Osteoclast Differentiation. J Endod. 2023 Sep;49(9):1129-1137. doi: 10.1016/j.joen.2023.07.005. Epub 2023 Jul 16. PMID: 37454872
• Ko HH, Peng HH, Cheng AN, Chou HE, Hou HH, Kuo WT, Liu WW, Kuo MY, Lee AY, Cheng SJ. Metastasis and immunosuppression promoted by mtDNA and PD-L1 in extracellular vesicles are reversed by WGP β-glucan in oral squamous cell carcinoma. Cancer Sci. 2023 Oct;114(10):3857-3872. doi: 10.1111/cas.15919. Epub 2023 Jul 31.
• Chen YW, Wu GH, Lee BS, Liu CT, Li HY, Cheng SJ, Kuo WT, Jeng JH, Chang PC, Lin CP, Chou HE, Hou HH. Third-generation sequencing-selected Scardovia wiggsiae promotes periodontitis progression in mice. J Periodontal Res. 2023 Feb;58(1):155-164.
• Wei, L. Y., Lin, H. C., Tsai, F. C., Ko, J. Y., Kok, S. H., Cheng, S. J., . . . Chia, J. S. (2022). Effects of Interleukin-6 on STAT3-regulated signaling in oral cancer and as a prognosticator of patient survival. Oral Oncology, 124. doi: 10.1016/j.oraloncology.2021.105665
• Wei, L. Y., Kok, S. H., Lee, Y. C., Chiu, W. Y., Wang, J. J., Cheng, S. J., . . . Lee, J. J. (2022). Prognosis of medication-related osteonecrosis of the jaws in metastatic prostate cancer patients. Oral Diseases, 28(1), 182-192. doi: 10.1111/odi.13737
• Tseng, H. Y., Chen, Y. W., Lee, B. S., Chang, P. C., Wang, Y. P., Lin, C. P., . . . Hou, H. H. (2022). The neutrophil elastase-upregulated placenta growth factor promotes the pathogenesis and progression of periodontal disease. Journal of Periodontology, 93(9), 1401-1410. doi: 10.1002/jper.21-0587
• Lo, Y. W., Lee, A. Y. L., Liu, Y. C., Ko, H. H., Peng, H. H., Lee, H. C., . . . Cheng, S. J. (2022). beta-glucan therapy converts the inhibition of myeloid-derived suppressor cells in oral cancer patients. Oral Diseases, 28(6), 1484-1495. doi: 10.1111/odi.13827
• Juan, Y. C., Su, Y. F., Bai, C. H., Fan, Y. C., Kuo, T. T., Ko, H. H., . . . Cheng, S. J. ZNF582 hypermethylation as a prognostic biomarker for malignant transformation of oral lesions. Oral Diseases. doi: 10.1111/odi.13946
• Wei, L. Y., Kok, S. H., Lee, Y. C., Chiu, W. Y., Wang, J. J., Cheng, S. J., . . . Lee, J. J. (2021). Prognosis of medication-related osteonecrosis of the jaws in cancer patients using antiresorptive agent zoledronic acid. Journal of the Formosan Medical Association, 120(8), 1572-1580. doi: 10.1016/j.jfma.2020.11.017
• Wang HW, Kok SH, Yang CN, Hong CY, Chi CW, Chen MH, Cheng SJ, Shun CT, Yang H, Lin SK. Blockade of fatty acid signaling inhibits lipopolysaccharide-induced macrophage recruitment and progression of apical periodontitis. Journal: International Endodontic Journal. Jan 2021 Jun;54(6):902-915. DOI: 10.1111/iej.13468.
• Peng, H. H., Ko, H. H., Chi, N. C., Wang, Y. P., Lee, H. C., Pan, P. Y., . . . Cheng, S. J. (2020). Upregulated NPM1 is an independent biomarker to predict progression and prognosis of oral squamous cell carcinomas in Taiwan. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 42(1), 5-13. doi: 10.1002/hed.25971
• Wei LY, Kok SH, Lee YC, Wang CC, Cheng SJ, Chang HH, Lee JJ. Prognosis of Medication-Related Osteonecrosis of the Jaws in Cancer Patients Using Antiresorptive Agent Zoledronic Acid. JFMA. 2020 Dec 11:S0929-6646(20)30594-5.
• Cheng, A. N., Cheng, L. C., Kuo, C. L., Lo, Y. K., Chou, H. Y., Chen, C. H., . . . Lee, A. Y. L. (2020). Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1-mediated immunoescape via STING-IFN signaling and extracellular vesicles. Journal for Immunotherapy of Cancer, 8(2). doi: 10.1136/jitc-2020-001372
• Wu, Y. H., Wu, Y. C., Chu, F. Y., Cheng, S. J., Sun, A., & Chen, H. M. (2019). Significantly higher frequencies of hematinic deficiencies and hyperhomocysteinemia in oral precancer patients. Journal of the Formosan Medical Association, 118(9), 1299-1307. doi: 10.1016/j.jfma.2019.05.016
• Wu, Y. H., Wu, Y. C., Cheng, S. J., Kuo, Y. S., Sun, A., & Chen, H. M. (2019). Gastric parietal cell and thyroid autoantibodies in oral precancer patients. Journal of the Formosan Medical Association, 118(10), 1393-1400. doi: 10.1016/j.jfma.2019.05.017
• Chou, H. C., Lin, H. W., Yang, J. H., Lin, P. Y., Cheng, S. J., Wu, Y. H., & Kuo, Y. S. (2019). Clinical outcomes of oral cancer patients who survive for more than 5 years in Taiwan. Journal of the Formosan Medical Association, 118(12), 1616-1622. doi: 10.1016/j.jfma.2019.07.022
• Ko, H. H., Peng, H. H., Cheng, S. J., & Kuo, M. Y. P. (2018). Increased salivary AKR1B10 level: Association with progression and poor prognosis of oral squamous cell carcinoma. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 40(12), 2642-2647. doi: 10.1002/hed.25370
• Cheng, S. J., Ko, H. H., Lee, J. J., & Kok, S. H. (2018). Comparison of long-term outcomes between pull-through resection and mandibular lip-split surgery for T4a tongue/floor of mouth cancers. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 40(1), 144-153. doi: 10.1002/hed.24994
• Cheng, S. J., Chang, C. F., Ko, H. H., Lee, J. J., Chen, H. M., Wang, H. J., . . . Chiang, C. P. (2018). Hypermethylated ZNF582 and PAX1 genes in mouth rinse samples as biomarkers for oral dysplasia and oral cancer detection. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 40(2), 355-368. doi: 10.1002/hed.24958