張定國醫師詳細介紹

骨科部主任

脊椎骨科主任

高壓氧中心主任

資深主治醫師

部定副教授

中華民國骨科醫學會監事

台灣脊椎外科醫學會理事

台灣脊椎微創醫學會理事

陽明大學工學博士

台大醫學院醫學系

101年赴法 Department of Spine Surgery, CHU de Bordeaux, France

103年赴南京鼓樓醫院

骨科專科醫師

外科專科醫師

中華民國高壓暨海底醫學會專科醫師

台灣脊椎外科醫學會監事

醫學會會員：骨科醫學會、高壓氧醫學會、脊椎外科醫學會、骨科創傷醫學會、外科醫學會、脊椎微創醫學會、關節重建醫學會

一般骨科、骨折外傷、脊椎手術、脊椎微創、脊柱側彎、骨質疏鬆、高壓氧治療

Ting-Kuo Chang, You-Han Zhong, Shan-Chi Liu, Chien-Chung Huang,Chun-Hao Tsai, Hsiang-Ping Lee, Shih-Wei Wang, Chin-Jung Hsuand Chih-Hsin Tang   Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway   Frontiers in Immunology 2021; doi: 10.3389/fimmu.2021.737990

Yu-Han Wang, Chun-Hao Tsai, Shan-Chi Liu, Hsien-Te Chen, Jun-Way Chang, Chih-Yuan Ko, Chin-Jung Hsu, Ting-Kuo Chang*, Chih-Hsin Tang*   miR-150-5p and XIST interaction controls monocyte adherence: Implications for osteoarthritis therapy.   Frontiers in Immunology 2022; Sep 20;13:1004334  DOI 10.3389/fimmu.2022.1004334

Yu-Ching Huang, Ting-Kuo Chang*   Bosworth fracture treated with immediate open reduction and internal fixation 6 hours after injury: A case report   Formosan Journal of Musculoskeletal Disorders 2020, 11 (2020) 136-140

Ting-Kuo Chang,Yu-Han Wang, Shu-Jui Kuo, Shih-Wei Wang, Chun-Hao Tsai, Yi-Chin Fong, Nan-Lin Wu, Shan-Chi Liu, Chih-Hsin Tang  Apelin enhances IL-1β expression in human synovial fibroblasts by inhibiting miR-144-3p through the PI3K and ERK pathways   AGING-US 2020, 2020, Vol. 12, No. 10, 9224-9239 (IF:4.831)

Chen-Yu Yang, Chi Chen, Cheng-Yung Lin, Yi-Hsuan Chen, Chih-Yang Lin, Chih-Wen Chid, Yu-Jen Chen, Shih-Chia Liu, Ting-Kuo Chang, Chih-Hsin Tang, Yu-Wei Lai, Huai-Jen Tsai, Jih-Jung Chen, Shih-Wei Wang  Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTOR-dependent pathways in human endothelial progenitor cells   Phytomedicine 2019, Nov;64:152911. doi: 10.1016/j.phymed.2019.152911. Epub 2019 Apr 2. (IF:4.18)

Ting-Kuo Chang, Ching-Chi Hsu   Comparison of Different Pullout Test Setups for Evaluation of Bone–Implant Interfacial Strength of Anterior Lumbar Interbody Fusion Devices   Journal of Medical and Biological Engineering 2019, https://doi.org/10.1007/s40846-018-0392-z (IF:1.306)

Chang TK, Ching-Chi Hsu, Ming-An Yang, and Devina Sutaji Effects of Fusion Device Designs on Spine Biomechanics IEEE Consumer Electronics Magazine 2019,8(2):84 - 89 (SCI,COMPUTER SCIENCE, HARDWARE & ARCHITECTL) (IF:3.273, 10/52=19.2%)

Ting-Kuo Chang, Ching-Chi Hsu   Comparison of Different Pullout Test Setups for Evaluation of Bone–Implant Interfacial Strength of Anterior Lumbar Interbody Fusion Devices    Journal of Medical and Biological Engineering 2019,39(1):117-125

Lai YS, Chen WC, Huang CH, Cheng CK, Chan KK, Chang TK*, The effect of graft strength on knee laxity and graft in-situ forces after posterior cruciate ligament reconstruction, PLOS ONE, 2015 May 22; 10(5):e0127293 (SCI, Multidisciplinary sciences)(IF:3.234, 8/56=14.2%) (Corresponding author)

Lu YC, Chang TK, Yeh ST, Fang HW, Lin CY, Hsu LI, Huang CH, Huang CH. The potential role of strontium ranelate in treating particle-induced osteolysis. Acta Biomaterialia. 2015;20:147-154. (SCI, Engineering, Biomedical)(IF:6.025, Ranking:3/76=3.9%) (Co-first author)

TING-KUO CHANG, CHING-CHI HSU*, KUAN-TING CHEN   Optimal screw orientation for the fixation of cervical degenerative disc disease using nonlinear C3-T2 multi-level spinal models and neuro-genetic algorithms   Acta of Bioengineering and Biomechanics 2015, 17(3)

Chen LP, Chang TK*, Huang TY, Kowk TG, Lu YC, “The correlation between lateral bowing angle of the femur and the location of atypical femur fractures” Calcif Tissue Int. 2014; 95(3):240-7. (SCI, Endocrinology & Metabolism)(IF:3.272, Ranking: 55/128=43%) (Corresponding author)

Ching-Chi Hsu, Ting-Kuo Chang, Dinh Cong Huy   Biomechanical Comparison of Different Vertebral Plate Designs for Anterior Cervical Discectomy and Fusion Using Nonlinear C3-T2 Multi-Level Spinal Models   Computer-Aided Design & Applications 2014,12(2) : 1–6

Ting-Kuo Chang*, Chang-Hung Huang, Yueh-Ching Liu, Wen-Chuan Chen, Colin J. McClean, Yu-Shu Lai, Cheng-Kung Cheng   Biomechanical Evaluation and Comparison of Polyetheretherketone Rod System to Traditional Titanium Rod Fixation on Adjacent Levels  Formosan Journal of Musculoskeletal Disorders 2013, 4(2):42-47