張源清醫師詳細介紹

馬偕紀念醫院乳房中心主任 台灣乳房醫學會 監事 教育部部定助理教授 腫瘤外科/乳房外科專科醫師暨指導醫師 馬偕紀念醫院一般外科資深主治醫師

國立台灣大學 生理學研究所博士 國立台灣大學 臨床醫學研究所碩士 中國醫藥大學 醫學士

台灣乳房腫瘤手術暨重建醫學會常務監事 乳房專科醫師 消化系外科專科醫師

乳癌手術暨藥物治療/乳癌臨床試驗

1. Lu YS, Lee KS, Chao TY, Tseng LM, Chitapanarux I, Chen SC, Liu CT, Sohn J, Kim JH, Chang YC, Yang Y, Shotelersuk K, Jung KH, Valenti R, Slader C, Gao M, Park YH*. A Phase Ib study of alpelisib or buparlisib combined with tamoxifen plus goserelin in premenopausal women with HR-positive HER2-negative advanced breast cancer. Clinical Cancer Research (in press) doi:10.1158/1078-0432.CCR-20-1008. PMID:32718997 2. Shao Z*, Pang D, Yang H, Li W, Wang S, Cui S, Liao N, Wang Y, Wang C, Chang YC, Wang H, Kang SY, Seo JH, Shen K, Laohawiriyakamol S, Jiang Z, Li J, Zhou J, Althaus B, Mao Y, Eng-Wong J. Efficacy, safety, and tolerability of pertuzumab, trastuzumab, and docetaxel for patients with early or locally advanced ERBB2-positive breast cancer in Asia: The PEONY phase 3 randomized clinical trial. JAMA Oncology 2019;6:e193692. doi:10.1001/jamaoncol.2019.3692. PMID:31647503 3. Chien-Liang Liu, Ming-Jen Chen, Jiunn-Chang Lin, Chi-Hsin Lin, Wen-Chien Huang, Shih-Ping Cheng, Shan-Na Chen, and Yuan-Ching Chang (corresponding author) Doxorubicin Promotes Migration and Invasion of Breast Cancer Cells through the Upregulation of the RhoA/MLC Pathway J Breast Cancer. 2019 Jun;22(2):185-195 4. Yuan-Ching Chang, Chi-Hsin Lin, Jiunn-Chang Lin, Shih-Ping Cheng, Shan-Na Chen, and Chien-Liang Liu, Inhibition of 3b-Hydroxysteroid Dehydrogenase Type 1 Suppresses Interleukin-6 in Breast Cancer J Surg Res. 2019,17;241:8-14. 5. Yu‑Ling Lin , Nu‑Man Tsai, Chia‑Hung Chen, Yen‑Ku Liu, Chung‑Jen Lee, Yi‑Lin Chan, Yu‑Shan Wan, Yuan‑Ching Chang, Chi‑Hsin Lin, Tse‑Hung Huang, Chao Ching Wang, Kwan‑Hwa Chi, and Kuang‑Wen Liao Specific drug delivery efficiently induced human breast tumor regression using a lipoplexnby non‑covalent association with anti‑tumor antibodies J Nanobiotechnol (2019) 17:25 6. Chuang YC, Wu HY, Lin YL, Tzou SC, Chuang CH, Jian TY, Chen PR, Chang YC, Lin CH, Huang TH, Wang CC, Chan YL, Liao KW Blockade of ITGA2 Induces Apoptosis and Inhibits Cell Migration in Gastric Cancer. Biol Proced Online. 2018; 20: 10. 7. Yuan-Ching Chang, , Chi-Kuan Chen, Ming-Jen Chen,, Jiunn-Chang Lin, Chi-Hsin Lin,Wen-Chien Huang, Shih-Ping Cheng, Shan-Na Chen, Chien-Liang Liu, MD Expression of 3b-Hydroxysteroid Dehydrogenase Type 1 in Breast Cancer is Associated with Poor Prognosis Independent of Estrogen Receptor Status Ann Surg Oncol (2017) 24:4033–4041 8. Yuan-Ching Chang, Chien-Liang Liu, Tsang-Pai Liu, Po-Sheng Yang, Ming-Jen Chen, Shih-Ping Cheng. Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta-Analysis of Randomized Controlled Trials Pain Pract 2016 Feb 23 DOI: 10.1111/papr.12442 9. I-Chun Chen, Yuan-Ching Chang, Yen-Shen Lu, Kuei-Pin Chung, Chiun-Sheng Huang, Tzu-Pin Lu, Wen-Hung Kuo, Ming-Yang Wang, Kuan-Ting Kuo, Pei-Fang Wu, Tsu-Hsin Hsueh, Chen-Yang Shen, Ching-Hung Lin & Ann-Lii Cheng Clinical Relevance of Liver Kinase B1(LKB1) Protein and Gene Expression in Breast Cancer Scientific Reports 6, 2016 Feb Article number: 21374 doi:10.1038/srep21374 10. Inhibition of breast cancer with transdermal tamoxifen‑encapsulated lipoplex Yu‑Ling Lin, Chia‑Hung Chen, Hsin‑Yi Wu, Nu‑Man Tsai, Ting‑Yan Jian, Yuan‑Ching Chang, Chi‑Hsin Lin, Chih‑Hsiung Wu, Fei‑Ting Hsu, Ting Kai Leung and Kuang‑Wen Liao J Nanobiotechnol (2016) 14:11 11. Yi Du, Hirohito Yamaguchi, Yongkun Wei, Jennifer L. Hsu, Hung-Ling Wang, Yi-Hsin Hsu, Wan-Chi Lin, Wen-Hsuan Yu, Paul G. Leonard, Gilbert R. Lee IV, Mei-Kuang Chen, Katsuya Nakai, Ming-Chuan Hsu, Chun-Te Chen, Ye Sun1, Yun Wu, Wei-Chao Chang, Wen-Chien Huang, Chien-Liang Liu, Yuan-Ching Chang, Chung-Hsuan Chen, Morag Park, Philip Jones, Gabriel N. Hortobagyi, and Mien-Chie Hung, Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors Nature Medicine 2016 Feb doi:10.1038/nm.4032 12. Yi-Hsin Hsu, Jun Yao, Li-Chuan Chan, Ting-Jung Wu, Jennifer L. Hsu, Yueh-Fu Fang, Yongkun Wei, Yun Wu, Wen-Chien Huang, Chien-Liang Liu, Yuan-Ching Chang, Ming-Yang Wang, Chia-Wei Li, Jia Shen, Mei-Kuang Chen, Aysegul A. Sahin, Anil Sood, Gordon B. Mills, Dihua Yu, Gabriel N. Hortobagyi, Mien-Chie Hung, Definition of PKC-a, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer Cancer Res 2014; 74(17); 4822–35. 13. Yuan-Ching Chang, Yi-Chiung Hsu, Chien-Liang Liu, Shih-Yuan Huang, Meng-Chun Hu, Shih-Ping Cheng Local Anesthetics Induce Apoptosis in Human Thyroid Cancer Cells through the Mitogen-Activated Protein Kinase Pathway 2014 DOI: 10.1371/journal.pone.0089563 14. Yuan-Ching Chang, Chien-Liang Liu, Ming-Jen Chen, Yung-Wei Hsu, Shan-Na Chen, Chi-Hsin Lin, Chin-Man Chen, Feng-Ming Yang, Meng-Chun Hu, .Local Anesthetics Induce Apoptosis in Human Breast Tumor Cells Anesthesia and Analgesia (2014) 118 (1): 116-24