孫瑜醫師詳細介紹

臺灣大學預防醫學研究所博士
中國醫藥大學醫學系

臺大醫院神經部住院醫師
臺大醫院神經部總醫師
臺大醫院神經部兼任主治醫師
羅東博愛醫院主治醫師
獲獎榮譽
2021 第17屆亞太神經學國際會議優秀論文獎-銀牌獎(腦中風組)
2009 腦中風醫學會 PAD and Stroke 國際研討會論文獎第一名
2008 指導住院醫師研究獲臺灣神經醫學會壁報優秀論文獎 -- 神經影像組
2008 臺灣神經醫學會壁報優秀論文獎 -- 腦中風組
2005 臺灣腦中風醫學會論文獎第二名
2002 第五屆杜世彬博士紀念論文獎第一名
2000 臺灣神經醫學會壁報優秀論文獎
獲邀至國內外醫學會年會、國際或全國性學術會議發表專題演講
2025 阿茲海默症精準醫療高峰會 - From biomarkers to clinical course: Insight into preclinical Alzheimer’s disease
2025 台灣神經免疫醫學會年度學術研討會 – Sleep disorders in autoimmune encephalitis
2025 第八屆亞太神經生理國際研討會 - Circadian rhythm and sleep-related disorders: the role of wearable devices
2025 台灣睡眠醫學會年度學術研討會 - Resetting the Biological Clock: How Lemborexant Helps Restore Circadian Rhythms and Natural Sleep in Insomnia Patients
2024 藥師公會- 阿茲海默氏症診斷新進展
2023 臺灣腦中風學會年會- The therapeutic role of neurotrophic factors in vascular dementia
2023 臺灣睡眠醫學會年會- Delirium and Sleep
2023 臺灣臨床神經生理學學會年會- Association of sleep with mental health and life expectancy
2023 第四屆臺灣國際神經醫學大會ITCN暨2023臺灣神經學會年會-Sleep Apnea and Stroke
2023 臺灣肌肉骨骼神經超音波醫學會-中風病人的spasticity治療(示範醫師)
2022 臺日失智照護科技/技術論壇-台灣失智症流行病學研究
2021 藥師公會-認識失智症與老人用藥安全
2018臺灣腦中風學會年會-Neurointensive Management of Stroke and Related Disorders
2017全球失智症報告-失智症健康照護路徑的成本
2016臺灣腦中風學會年會-The Best and Worst Case Scenarios in the Stroke Prevention of Atrial Fibrillation
2014臺灣神經生理技術學會年會-Sleep related Neurologic Disorders
2014香港腦中風學會年會-The Efficacy and Safety of Cilostazol in Ischemic Stroke Patients with Peripheral Arterial Disease
2014臺灣腦中風學會年會-High Risk of Stroke Patients with Peripheral Artery Disease in Taiwan
2014臺灣醫學會春季學術演講會-糖尿病藥物的中風風險
2014社團法人台灣失智症協會、台灣臨床失智症學會-失智症流行病學調查之研究設計
2013臺灣公共衛生學會年會-輕度認知功能障礙及失智症盛行率之全國性調查
2013 International Conference of Alzheimer’s Disease International-Epidemiological Study of Dementia (Including Mild Cognitive Impairment) in Taiwan
2012韓國腦中風學會年會-International Guideline Review in 2nd Stroke prevention
2012臺灣醫學會年會-失智症藥物預防與治療的新進展
參與國際性多國多中心或國內的臨床試驗或專題研究計劃擔任主持人或共同/協同主持人
一、臨床試驗研究計劃或專題研究計劃：
2025 用深度學習依據到院時電腦斷層來預測血栓溶解或取栓治療急性缺血性腦中風的預後 (ECKH_D11401)
2025 腦血管疾病致病機轉及預後之觀察追蹤研究 (201911029RINB)
2023 一項第3期、隨機分配、雙盲、平行組、安慰劑對照試驗，證明一種口服凝血因子 XIa 抑制劑 Milvexian 在急性缺血性中風或高風險暫時性腦缺血發作後用於預防中風的療效和安全性 (ECKIRB1120501)
2022 一項多國多中心、隨機分配、安慰劑對照、雙盲、平行分組與事件驅動的第三期試驗、研究口服Fxla抑制劑asundexian(BAY2433334)用於18歲以上之男性和女性參與者，以預防在急性非心因性缺血性中風或高風險暫時性腦缺血後發生缺血性中風 (ECKIRB1111204)
2022 癲癇患者其交通事故、住院風險、住院嚴重度及醫療利用之研究(ECKH_D11001)
2022 血管性認知障礙之機轉及介入 (ECKIRB1110701)
2021 透過數據資料與AI平台結合開發新穎生物標記以減少中風之疾病負擔：從中風預防到中風之精準醫療照護 (ECKIRB1100603)
2021 運用遠距式光體積變化描記圖來偵測心房顫動 (ECKIRB1100602)
2021 阿茲海默症患者的存活分析：1998至2017的世代研究 (ECKIRB1100505)
2021 癲癇患者其交通事故、住院風險、住院嚴重度及醫療利用之研究 (ECKIRB1100101)
2020 臺灣急性缺血性腦中風動脈血栓移除術登錄 (ECKIRB1090101)
2020 使用畫鐘法和深度學習快速評估認知障礙 (ECKIRB1090601)
2019 神經退化性疾病之中文語言評估測驗 (ECKIRB1081101)
2019 複方益生菌應用於阿茲海默氏症之臨床療效 (ECKIRB1080701)
2019 中文版社區整合量表修訂版於腦中風病人之信效度檢定 (ECKIRB1081004)
2019 應用基因篩檢以預防一線抗癲癇藥物引發之致命性過敏 (ECKIRB1080901)
2019 一項隨機分配、雙盲、安慰劑對照的多國多中心第三期試驗，探討以Ticagrelor合併ASA相較於使用ASA治療急性缺血性腦中風或暫時性腦缺血之患者，預防中風及死亡的療效及安全性[THALES-使用Ticagrelor合併ASA治療急性腦中風或暫時性腦缺血，以預防中風及死亡] (ECKIRB1080304)
2019 運用遠距式光體積變化描記圖來偵測心房顫動 (ECKIRB1080306)
2017 一項多國多中心、隨機分配、雙盲、有效藥對照之第三期臨床試驗以評估donepezil穿皮貼片於阿茲海默症患者之療效及安全性 (ECKIRB1060701)
2017 空氣污染與頭部創傷環境曝露因子與基因之交互作用對於巴金森氏病發生之影響(ECKIRB1060502)
2016開發應用基因篩檢以預防常見癲癇藥物癲能停(phenytoin)引發之致命過敏反應(ECKIRB1050301)
2015比較Tenecteplase (TNK)與Alteplase (t-PA)在中風血栓溶解效果的臨床試驗 (多國) (ECKIRB1041001)
2015 一個隨機、雙盲、多國多中心的試驗，比較Ticagrelor與阿斯匹靈(ASA)對於罹患急性缺血性腦中風或短暫性腦缺血發作之患者，其預防重大血管事件的效果。[SOCRATES –以阿斯匹靈或Ticagrelor治療急性中風及短暫性腦缺血發作及病患結果 (多國) (ECKIRB1040402)
2015 腦中風急性期之頭部擺位研究 (多國) (ECKIRB1040503)
2015 以磁量阿茲海默症免疫磁減量檢測試劑偵測阿茲海默症患者或因阿茲海默症導致輕度知能障礙患者血漿生物標記的臨床診斷確效評估試驗 (ECKIRB1040102)
2014 乙醯膽鹼酶抑制劑的持續使用是否能降低阿茲海默失智症患者的死亡率與醫療費用？-以台灣人口為基礎的研究 (ECKIRB1030407)
2014 台灣中風登錄 (ECKIRB1030203)
2013 非瓣膜性心房纖維顫動患者併有中風或暫時性腦缺血發作病史服用 Dabigatran 之多中心登錄研究–非介入性、觀察性研究 (多國) (ECKIRB1021003)
2013 以一隨機、雙盲多中心臨床研究，針對缺血性中風復原，比較併用BNG-1及Aspirin與單獨使用Aspirin之功能性結果與安全性 (ECKIRB1021001)
2013 NSC 102-2314-B-385-001-降血壓與降血脂藥物對巴金森氏病的風險研究(ECKIRB1020702)
2013 隨機分配、雙盲、安慰劑對照、平行組別、為期12個月以Leuco-methylthioninum bis(hydromethanesulfonate)治療輕度至中度阿茲海默症患者之臨床試驗 (多國) (ECKIRB 201303018)
2012 受試者發生急性缺血性中風後3-6小時內接受懷特血寶注射劑的隨機、雙盲、安慰劑對照試驗 (Pass) (ECKIRB 201208001)
2012 延長血栓溶劑治療急性神經不全疾病(多國) EXTEND (International) (ECKIRB 201208009)
2012 酒精依賴症候群的神經學併發症及醫療花費 (兩年期) (ECKIRB 201210037)
2011 Cilostazol用在缺血性腦中風病患合併周邊動脈疾病的療效與安全性 (SPAD) (ECKIRB110501)
二、科技部專題研究計劃主持人或共同主持人:
共同主持人: 2022-2025 影像式心房顫動與心律不整偵測研究與系統實現 (計畫編號: MOST 111-2221-E-A49 -166 -MY3)
共同主持人: 2023-2025 應用深度學習於輕度認知障礙失智症畫鐘測驗評估之實證研究 (計畫編號: NSTC 112-2221-E-305-007-, NSTC 113-2221-E-305-011)
共同主持人: 2022-2023 失智症和憂鬱症之相關性和其共病對醫療利用及自殺風險之影響 (計畫編號: MOST 110-2410-H-468-015)
共同主持人: 2020-2021 失智症與交通事故住院風險、住院嚴重度及醫療利用之相關 (計畫編號: MOST110-2410-H468-001)
共同主持人: 2016-2021 台灣中風臨床試驗聯盟 III (2016-2017 計畫編號:105-2325-B-039-003-IV, 2017-2018 計畫編號: 106-2321-B-039-005- (計畫編號: 109-2321-B-039-002-, 2019-2020 計畫編號: 108-2321-B-039-003-)
甲、 台灣中風臨床試驗聯盟 IV (2020-2021 計畫編號: 109-2321-B-039-002-)
共同主持人: 2014-2016 創傷性腦損傷與巴金森氏病共病症之長期追蹤研究 (計畫編號: MOST103-2314-B-227-002-MY2)
計劃主持人: 2013-2014 降血壓與降血脂藥物對巴金森氏病的風險研究 (計畫編號: NSC 102-2314-B-385-001-)
共同主持人: 2012-2013 以社區為基礎之認知障礙老人的電腦化認知訓練方案之建立與成效的探討 (計畫編號: NSC101-2314-B570-001)
計劃主持人: 2010-2012 睡眠中自主神經功能與中風之相關性研究 (計畫編號: NSC99-2314-B385-002-MY2)
計劃主持人: 2003-2004 隨機雙盲方法試驗以維他命複方降低血清中半胱胺酸濃度研究對失智症及阿茲海默症認知功能之改善 (計畫編號: NSC92-2314-B385-002)
三、衛生福利部委託研究計畫:
協同主持人: 2018-2020 我國庫賈氏病之發生、臨床病程及流行病學相關因子分析研究 (計畫編號: MOHW107-CDC-C-114-113501)
協同主持人: 2011-2013 失智症(含輕度認知功能障礙MCI)流行病學調查及失智症照護研究計畫 (計畫編號: DOH100-TD-M-113-100001)
四、臨床試驗藥物資料安全監測委員會或外部審查專家:
2023 臨床試驗: 一項開放性、劑量遞增臨床一期研究用於評估 UMC119-06經靜脈輸注於急性缺血性腦中風患者之安全性及耐受性(外部審查委員)
2016~2018　臨床試驗:UNSV203-AD多國多中心臨床試驗藥物資料安全監測委員會(DSMB)主席
2016~2018　臨床試驗:RGN1016多中心臨床試驗藥物資料安全監測委員會(DSMB)委員

恩主公醫院神經科主任
臺大醫學院醫學系神經科兼任副教授
教育部部定副教授
臺灣神經學會睡眠醫學組主委
臺灣睡眠醫學會睡眠專科醫師認證核心課程小組委員
衛生福利部疾病管制署庫賈氏病諮詢委員會委員
衛生福利部國民健康署戒菸服務審查專家
臺灣臨床失智症學會教育委員會委員
台灣失智症協會學術編輯委員會委員
新北市失智症協會理事
新北市政府消防局醫療指導顧問

失智症
睡眠障礙
腦中風
一般神經醫學

臺灣神經醫學會
臺灣腦中風學會
神經重症加護學會
臺灣臨床失智症學會
臺灣動作障礙學會
臺灣睡眠醫學會
專科醫師
神經科專科醫師
神經重症加護專科醫師
睡眠醫學專科醫師

一、發表於國際期刊的研究論文 (*通訊作者)
Yeh S. J., Chen C. H., Lin Y. H., Tsai L. K., Lee C. W., Sun Y*., Tang SC*., Jeng J. S. Ferroptosis biomarkers predict the outcomes of patients with acute ischemic stroke undergoing endovascular thrombectomy. Sci Rep. Nov 11 2025;15(1):39510. doi:10.1038/s41598-025-23289-0
Chen KC, Ku LE, Hu YH, Sun Y, Elbaz A, Lee PC. Healthcare utilization and costs for patients with Parkinson's disease in Taiwan. BMC Neurol. 2025;25:3. doi: 10.1186/s12883-024-03988-3
Sun Y, Liu CC, Li CY, Chiu MJ. Survival After the Diagnosis of Mild-to-Moderate Alzheimer's Disease Dementia: A 15-Year National Cohort Study in Taiwan. Int J Geriatr Psychiatry. 2024;39(9):e6152.
Tseng CW, Wu BF, Sun Y. A Real-Time Contact-Free Atrial Fibrillation Detection System for Mobile Devices. IEEE journal of biomedical and health informatics. 2024;Pp. doi: 10.1109/jbhi.2024.3422155
Sun Y, Ku MY, Liu CC, Chien LN. Characteristics of motor vehicle crashes and fatality risk among drivers with epilepsy. Epilepsia. 2024. doi: 10.1111/epi.18097
Wu YC, Lin CH, Chiu LW, Wu BF, Chung ML, Tang SC, Sun Y*. Contact-Free Atrial Fibrillation Screening With Attention Network. IEEE journal of biomedical and health informatics. 2024;28:5124-5135. doi: 10.1109/jbhi.2024.3368049
Egle M, Wang WC, Fann YC, Johansen MC, Lee JT, Yeh CH, Jason Lin CH, Jeng JS, Sun Y, Lien LM, Gottesman RF. Sex Differences in the Role of Multimorbidity on Poststroke Disability: The Taiwan Stroke Registry. Neurology. 2024;102:e209140. doi: 10.1212/wnl.0000000000209140
Tee, B.L.; Li-Ying, L.K.; Chen, T.F.; Yan, C.T.; Tsoh, J.; Chan, A.L.; Wong, A.; Lo, R.Y.; Lu, C.J.; Sun, Y., et al. More than a piece of cake: Noun classifier processing in primary progressive aphasia. Alzheimers Dement 2024, 10.1002/alz.13701, doi:10.1002/alz.13701.
Lin, C.H.; Chen, Y.A.; Jeng, J.S.; Sun, Y.; Wei, C.Y.; Yeh, P.Y.; Chang, W.L.; Fann, Y.C.; Hsu, K.C.; Lee, J.T. Predicting ischemic stroke patients' prognosis changes using machine learning in a nationwide stroke registry. Med Biol Eng Comput 2024, 10.1007/s11517-024-03073-4, doi:10.1007/s11517-024-03073-4.
Hou KC, Chen YC, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chiou JM, Chen JH. Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities. J Formos Med Assoc. 2024. doi: 10.1016/j.jfma.2024.04.018
Hsu YC, Huang YY, Tsai SY, Kuo YW, Lin JH, Ho HH, Chen JF, Hsia KC, Sun Y*. Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer's Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study. Nutrients. 2023;16. doi: 10.3390/nu16010016
Wu BF, Wu BJ, Cheng SE, Sun Y, Chung ML. Motion-Robust Atrial Fibrillation Detection Based on Remote-Photoplethysmography. IEEE journal of biomedical and health informatics. 2023;27(6):2705-16. doi:10.1109/jbhi.2022.3172705
Sun Y*, Tsai MK, Wen CP*. Association of sleep duration and sleeping pill use with mortality and life expectancy: A cohort study of 484,916 adults. Sleep health. 2023. doi:10.1016/j.sleh.2023.01.017
Yeh HL, Hsieh FI, Lien LM, Kuo WH, Jeng JS, Sun Y, Wei CY, Yeh PY, Yip HT, Lin CL, Huang N, Hsu KC: Patient and hospital characteristics associated with do-not-resuscitate/do-not-intubate orders: a cross-sectional study based on the Taiwan stroke registry. BMC palliative care 2023;22:138
Wang IK, Yen TH, Tsai CH, Sun Y, Chang WL, Chen PL, Lai TC, Yeh PY, Wei CY, Lin CL, Hsu KC, Li CY, Sung FC, Hsu CY: Renal function is associated with one-month and one-year mortality in patients with intracerebral hemorrhage. PLoS One 2023;18:e0269096
Wen CP, Lee YC, Sun YT, Huang CY, Tsai CH, Chen PL, Chang WL, Yeh PY, Wei CY, Tsai MJ, Sun Y, et al. Low-Density Lipoprotein Cholesterol and Mortality in Patients With Intracerebral Hemorrhage in Taiwan. Frontiers in neurology. 2022;12. doi:10.3389/fneur.2021.793471
Sun Y, Yang YY, Wu BJ, Huang PW, Cheng SE, Wu BF, Chen CC. Contactless facial video recording with deep learning models for the detection of atrial fibrillation. Scientific reports. 2022;12(1):281. doi:10.1038/s41598-021-03453-y
Lin SF, Hu HH, Chao HL, Ho BL, Chen CH, Chan L, Lin HJ, Sun Y, Lin YY, Chen PL, et al. Triglyceride-Glucose Index and Intravenous Thrombolysis Outcomes for Acute Ischemic Stroke: A Multicenter Prospective-Cohort Study. Frontiers in neurology. 2022;13:737441. doi: 10.3389/fneur.2022.737441
Lin SF, Chen CF, Hu HH, Ho BL, Chen CH, Chan L, Lin HJ, Sun Y, Lin YY, Chen PL, Lin SK, Wei CY, Lin YT, Lee JT, Chao AC. Comparison of Different Dosages of Alteplase in Atrial Fibrillation-Related Acute Ischemic Stroke After Intravenous Thrombolysis: A Nationwide, Multicenter, Prospective Cohort Study in Taiwan. Journal of the American Heart Association. 2022;11(3):e023032. doi:10.1161/jaha.121.023032
Yeh SJ, Tang SC, Tsai LK, Chen CH, Hsu SP, Sun Y, Lien LM, Wei CY, Lai TC, Chen PL, Chen CC, Huang PH, Lin CH, Liu CH, Lin HJ, Hu CJ, Lin CL, Jeng JS, Hsu CY. Renal Function-Dependent Associations of Statins with Outcomes of Ischemic Stroke. Journal of atherosclerosis and thrombosis. 2021;28(2):146-56. doi:10.5551/jat.55210
Wang IK, Yu TM, Yen TH, Chiu LT, Lien LM, Sun Y, Wei CY, Hsu KC, Lai PC, Li CY, Sung FC, Hsu CY. Renal dysfunction is associated with lower odds of home discharge for patients with stroke. Postgraduate medicine. 2021:1-8. doi:10.1080/00325481.2021.1964198
Sun Y, Fan LY, Huang CT, Liu CC, Chen TF, Lu CJ, Guo WY, Chang YC, Chiu MJ. Prognostic Features of Sporadic Creutzfeldt-Jakob Disease: An Analysis of Taiwan's Nationwide Surveillance. Journal of the American Medical Directors Association. 2021. doi:10.1016/j.jamda.2021.08.010
Liu HC, Chen HH, Ho CS, Chang JF, Lin CC, Chiu MJ, Chen TF, Hu CJ, Yan SH, Sun Y, Yang SY. Investigation of the Number of Tests Required for Assaying Plasma Biomarkers Associated with Alzheimer's Disease Using Immunomagnetic Reduction. Neurology and therapy. 2021;10(2):1015-28. doi:10.1007/s40120-021-00280-1
Liu CC, Liu CH, Sun Y*, Lee HJ, Tang LY, Chiu MJ. Rural-urban disparities in the prevalence of mild cognitive impairment and dementia in Taiwan: A door-to-door nationwide study. Journal of epidemiology / Japan Epidemiological Association. 2021. doi:10.2188/jea.JE20200602
Lin SF, Hu HH, Ho BL, Chen CH, Chan L, Lin HJ, Sun Y, Lin YY, Chen PL, Lin SK, Wei CY, Lin YT, Lee JT, Chao AC. Pre-treatment of Single and Double Antiplatelet and Anticoagulant With Intravenous Thrombolysis for Older Adults With Acute Ischemic Stroke: The TTT-AIS Experience. Frontiers in neurology. 2021;12:628077. doi:10.3389/fneur.2021.628077
Liang CL, Chen HJ, Lee YC, Wu CC, Tsai CH, Chen PL, Chang WL, Yeh PY, Wei CY, Tsai MJ, Sun Y, Lin CH, Lee JT, Lai TC, Lien LM, Lin MC, Lin CL, Wang HK, Hsu CY. Smoking Status and Functional Outcomes in Young Stroke. Frontiers in neurology. 2021;12:658582. doi:10.3389/fneur.2021.658582
Ho LC, Wang HK, Chiu LT, Wang HH, Lee YC, Hung SY, Sun Y, Wei CY, Hsu KC, Chen YW, Lien LM, Hsu CY. Protein energy wasting-based nutritional assessment predicts outcomes of acute ischemic stroke and solves the epidemiologic paradox. Nutrition (Burbank, Los Angeles County, Calif.). 2021;93:111431. doi:10.1016/j.nut.2021.111431
Chua SK, Hsieh FI, Hu CJ, Wang IK, Lee JT, Yeh HL, Lin KY, Lai TC, Sun Y, Jeng JS, Lin CL, Lien LM, Hsu CY. Prognostic impact of renal dysfunction on embolic stroke of undetermined source-Role beyond CHA(2) DS(2) -VASc score: Results from Taiwan Stroke Registry. Eur J Neurol. 2021;28(4):1253-64. doi:10.1111/ene.14662
Cheng CJ, Lu CY, Chang YH, Sun Y*, Chu HJ, Lee CY, Liu CH, Lin CH, Lu CJ, Li CY*. Effectiveness of the WHO-Authorized COVID-19 Vaccines: A Rapid Review of Global Reports till 30 June 2021. Vaccines. 2021;9(12). doi:10.3390/vaccines9121489
Chen YY, Sun Y, Hu YH, Li CY, Artaud F, Carcaillon-Bentata L, Elbaz A, Lee PC. Risk of Suicide Among Patients With Parkinson Disease. JAMA psychiatry. 2021;78(3):293-301. doi:10.1001/jamapsychiatry.2020.4001
Wang IK, Yen TH, Guo YC, Sun Y, Lien LM, Chang WL, Chen PL, Yang YC, Sung FC, Hsu CY. Antiplatelet agents for the secondary prevention of ischaemic stroke in patients with or without renal dysfunction. Eur J Neurol. 2020;27:572-578.
Wang IK, Yen TH, Chen CH, Hsu SP, Sun Y, Lien LM, Chang WL, Lai TC, Chen PL, Chen CC, Huang PH, Lin CH, Su YC, Lin MC, Li CY, Sung FC, Hsu CY. Intravenous tissue plasminogen activator for acute ischemic stroke in patients with renal dysfunction. Qjm. 2020.
Wang HK, Huang CY, Sun YT, Li JY, Chen CH, Sun Y, Liu CH, Lin CH, Chang WL, Lee JT, Sung SF, Yeh PY, Lai TC, Tsai IJ, Lin MC, Lin CL, Wen CP, Hsu CY. Smoking Paradox in Stroke Survivors?: Uncovering the Truth by Interpreting 2 Sets of Data. Stroke. 2020;51(4):1248-56.
Sun Y, Liu CC, Fan LY, Huang CT, Chen TF, Lu CJ, Guo WY, Chang YC, Chiu MJ. Incidence of and Mortality Due to Human Prion Diseases in Taiwan: A Prospective 20-Year Nationwide Surveillance Study from 1998 to 2017. Clin Epidemiol. 2020;12:1073-81.
Liu CC, Sun Y, Kung SF, Kuo HW, Huang NC, Li CY, Hu SC. Effects of physical and social environments on the risk of dementia among Taiwanese older adults: a population-based case-control study. BMC Geriatrics. 2020;20(1):226.
Lin CH, Hsu KC, Johnson KR, Fann YC, Tsai CH, Sun Y, Lien LM, Chang WL, Chen PL, Lin CL, Hsu CY. Evaluation of machine learning methods to stroke outcome prediction using a nationwide disease registry. Comput Methods Programs Biomed. 2020;190:105381.
Chiu MJ, Chen TF, Hu CJ, Yan SH, Sun Y, Liu BH, Chang YT, Yang CC, Yang SY. Nanoparticle-based immunomagnetic assay of plasma biomarkers for differentiating dementia and prodromal states of Alzheimer's disease - A cross-validation study. Nanomedicine. 2020;28:102182.
Ma H, Campbell BCV, Parsons MW, Churilov L, Levi CR, Hsu C, Kleinig TJ, Wijeratne T, Curtze S, Dewey HM, Miteff F, Tsai CH, Lee JT, Phan TG, Mahant N, Sun MC, Krause M, Sturm J, Grimley R, Chen CH, Hu CJ, Wong AA, Field D, Sun Y, Barber PA, Sabet A, Jannes J, Jeng JS, Clissold B, Markus R, Lin CH, Lien LM, Bladin CF, Christensen S, Yassi N, Sharma G, Bivard A, Desmond PM, Yan B, Mitchell PJ, Thijs V, Carey L, Meretoja A, Davis SM, Donnan GA. Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke. N Engl J Med. 2019;380(19):1795-803.
Liu CC, Sun Y, Lee PC, Li CY, Hu SC. Risk of dementia after Parkinson's disease in Taiwan: a population-based retrospective cohort study using National Health Insurance claims. BMJ Open. 2019;9(3):e025274.
Liu CC, Li CY, Kung SF, Kuo HW, Huang NC, Sun Y*, Hu SC*. Association of Environmental Features and the Risk of Alzheimer's Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study. Int J Environ Res Public Health. 2019;16(16).
Liu CC, Li CY, Kung SF, Kuo HW, Huang NC, Sun Y, Hu SC. Association of Environmental Features and the Risk of Alzheimer's Dementia in Older Adults: A Nationwide Longitudinal Case-Control Study. International journal of environmental research and public health. 2019;16(16).
Chen YW, Sung SF, Chen CH, Tang SC, Tsai LK, Lin HJ, Huang HY, Po HL, Sun Y, Chen PL, Chan L, Wei CY, Lee JT, Hsieh CY, Lin YY, Yeh SJ, Lien LM, Jeng JS. Intravenous Thrombolysis Administration 3-4.5 h After Acute Ischemic Stroke: A Retrospective, Multicenter Study. Front Neurol. 2019;10:1038.
Chao AC, Han K, Lin SF, Lin RT, Chen CH, Chan L, Lin HJ, Sun Y, Lin YY, Chen PL, Lin SK, Wei CY, Lin YT, Lee JT, Hu HH, Bai CH. Low-dose versus standard-dose intravenous alteplase for octogenerian acute ischemic stroke patients: A multicenter prospective cohort study. J Neurol Sci. 2019;399:76-81.
Wang IK, Liu CH, Yen TH, Jeng JS, Sung SF, Huang PH, Li JY, Sun Y, Wei CY, Lien LM, Tsai IJ, Sung FC, Hsu CY. Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke. Atherosclerosis. 2018;269:288-93.
Mao HF, Chang LH, Tsai AY, Huang WW, Tang LY, Lee HJ, Sun Y, Chen TF, Lin KN, Wang PN, Shyu YL, Chiu MJ. Diagnostic accuracy of Instrumental Activities of Daily Living for dementia in community-dwelling older adults. Age Ageing. 2018;47:551-7.
Lu CL, Chang YH, Sun Y, Li CY. A population-based study of epilepsy incidence in association with type 2 diabetes and severe hypoglycaemia. Diabetes research and clinical practice. 2018;140:97-106.
Ku LE, Li CY, Sun Y*. Can Persistence With Cholinesterase Inhibitor Treatment Lower Mortality and Health-Care Costs Among Patients With Alzheimer's Disease? A Population-Based Study in Taiwan. Am J Alzheimers Dis Other Demen. 2018;33(2):86-92.
Chi NF, Wen CP, Liu CH, Li JY, Jeng JS, Chen CH, Lien LM, Lin CH, Sun Y, Chang WL, Hu CJ, Hsu CY. Comparison Between Aspirin and Clopidogrel in Secondary Stroke Prevention Based on Real-World Data. J Am Heart Assoc. 2018;7(19):e009856.
Cheng CM, Chang WH, Chiu YC, Sun Y, Lee HJ, Tang LY, Wang PN, Chiu MJ, Yang CH, Tsai SJ, Tsai CF. Association of Polypharmacy With Mild Cognitive Impairment and Cognitive Ability: A Nationwide Survey in Taiwan. J Clin Psychiatry. 2018;79(6).
Wang IK, Liu CH, Yen TH, Jeng JS, Hsu SP, Chen CH, Lien LM, Lin RT, Chen AC, Lin HJ, Chi HY, Lai TC, Sun Y, Lee SP, Sung SF, Chen PL, Lee JT, Chiang TR, Lin SK, Muo CH, Ma H, Wen CP, Sung FC, Hsu CY. Cholesterol Levels Are Associated with 30-day Mortality from Ischemic Stroke in Dialysis Patients. J Stroke Cerebrovasc Dis. 2017;26(6):1349-56.
Tang SC, Yin JH, Liu CH, Sun MH, Lee JT, Sun Y, Hsu CS, Sun MC, Lin CH, Chen CH, Lien LM, Muo CH, Jeng JS, Hsu CY. Low Pulse Pressure After Acute Ischemic Stroke is Associated With Unfavorable Outcomes: The Taiwan Stroke Registry. J Am Heart Assoc. 2017;6(6).
Lee CY, Sun Y, Lee HJ, Chen TF, Wang PN, Lin KN, Tang LY, Lin CC, Chiu MJ. Modest Overweight and Healthy Dietary Habits Reduce Risk of Dementia: A Nationwide Survey in Taiwan. J Prev Alzheimers Dis. 2017;4(1):37-43.
Jeng JS, Hsieh FI, Yeh HL, Chen WH, Chiu HC, Tang SC, Liu CH, Lin HJ, Hsu SP, Lo YK, Chan L, Chen CH, Lin RT, Chen YW, Lee JT, Yeh CH, Sun MH, Lai TC, Sun Y, Sun MC, Chen PL, Chiang TR, Lin SK, Yip BS, Chen CI, Bai CH, Chen ST, Chiou HY, Lien LM, Hsu CY. Impact of MCA stenosis on the early outcome in acute ischemic stroke patients. PLoS One. 2017;12(4):e0175434.
Hou WH, Li CY, Chang HH, Sun Y, Tsai CC. A population-based cohort study suggests an increased risk of multiple sclerosis incidence in patients with type 2 diabetes mellitus. J Epidemiol. 2017;27(5):235-41.
Chen TB, Yiao SY, Sun Y, Lee HJ, Yang SC, Chiu MJ, Chen TF, Lin KN, Tang LY, Lin CC, Wang PN. Comorbidity and dementia: A nationwide survey in Taiwan. PLoS One. 2017;12(4):e0175475.
Weng PH, Chen JH, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen YC. CHRNA7 Polymorphisms and Dementia Risk: Interactions with Apolipoprotein ε4 and Cigarette Smoking. Scientific reports. 2016;6:27231.
Sun Y, Lin CC, Lu CJ, Hsu CY, Kao CH. Association Between Zolpidem and Suicide: A Nationwide Population-Based Case-Control Study. Mayo Clin Proc. 2016;91(3):308-15.
Liu CC, Li CY, Lee PC, Sun Y*. Variations in Incidence and Prevalence of Parkinson's Disease in Taiwan: A Population-Based Nationwide Study. Parkinsons Dis. 2016;2016:8756359.
Lee PC, Liu LL, Sun Y, Chen YA, Liu CC, Li CY, Yu HL, Ritz B. Traffic-related air pollution increased the risk of Parkinson's disease in Taiwan: A nationwide study. Environ Int. 2016;96:75-81.
Chen YC, Hsiao CJ, Jung CC, Hu HH, Chen JH, Lee WC, Chiou JM, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen CJ, Yang HI. Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer's Disease. Scientific reports. 2016;6:36155.
Chen JH, Hsieh CJ, Huang YL, Chen YC, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM. Genetic polymorphisms of lipid metabolism gene SAR1 homolog B and the risk of Alzheimer's disease and vascular dementia. J Formos Med Assoc. 2016;115(1):38-44.
Yeh SJ, Jeng JS, Tang SC, Liu CH, Hsu SP, Chen CH, Lien LM, Lin HJ, Chen CM, Lin RT, Lee SP, Lin CH, Yeh CH, Sun Y, Sun MH, Yin JH, Lin CC, Wen CP, Tsai LK, Sung FC, Hsu CY. Low estimated glomerular filtration rate is associated with poor outcomes in patients who suffered a large artery atherosclerosis stroke. Atherosclerosis. 2015;239(2):328-34.
Yang SY, Weng PH, Chen JH, Chiou JM, Lew-Ting CY, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen YC. Leisure activities, apolipoprotein E e4 status, and the risk of dementia. J Formos Med Assoc. 2015;114(12):1216-24.
Wu YC, Lin YC, Yu HL, Chen JH, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen YC. Association between air pollutants and dementia risk in the elderly. Alzheimer's & dementia (Amsterdam, Netherlands). 2015;1(2):220-8.
Sun Y, Lu CJ, Chen RC, Hou WH, Li CY. Risk of Amyotrophic Lateral Sclerosis in Patients With Diabetes: A Nationwide Population-Based Cohort Study. J Epidemiol 2015 Jun 5;25:445-51.
Lin KP, Chou YC, Chen JH, Chen CD, Yang SY, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen YC. Religious affiliation and the risk of dementia in Taiwanese elderly. Archives of gerontology and geriatrics. 2015;60(3):501-6.
Jeng JS, Sun Y, Lee JT, Lin RT, Chen CH, Po HL, Lin HJ, Liu CH, Sun MH, Sun MC, Chern CM, Lien LM, Chiu HC, Hu HH, Chiou HY, Chen ST, Ma H, Hsu CY. The efficacy and safety of cilostazol in ischemic stroke patients with peripheral arterial disease (SPAD): protocol of a randomized, double-blind, placebo-controlled multicenter trial. Int J Stroke 2015 Jan;10:123-7.
Hsieh CJ, Weng PH, Chen JH, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen YC. Sequence variants of the aging gene CISD2 and the risk for Alzheimer's disease. J Formos Med Assoc. 2015;114(7):627-32.
Fan LY, Sun Y, Lee HJ, Yang SC, Chen TF, Lin KN, Lin CC, Wang PN, Tang LY, Chiu MJ. Marital Status, Lifestyle and Dementia: A Nationwide Survey in Taiwan. PLoS One 2015;10:e0139154.
Sun Y, Lee HJ, Yang SC, Chen TF, Lin KN, Lin CC, Wang PN, Tang LY, Chiu MJ. A nationwide survey of mild cognitive impairment and dementia, including very mild dementia, in Taiwan. PLoS One 2014;9:e100303.
Weng PH, Chen JH, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen YC. CHRNA7 polymorphisms and response to cholinesterase inhibitors in Alzheimer's disease. PLoS One. 2013;8(12):e84059.
Lu CJ, Sun Y*, Muo CH, Chen RC, Chen PC, Hsu CY. Risk of Stroke with Thiazolidinediones: A Ten-Year Nationwide Population-Based Cohort Study. Cerebrovasc Dis 2013;36:145-51.
Huang HL, Kuo LM, Chen YS, Liang J, Chiu YC, Chen ST, Sun Y, Hsu WC, Shyu YI. A home-based training program improves caregivers' skills and dementia patients' aggressive behaviors: a randomized controlled trial. Am J Geriatr Psychiatry 2013 Nov;21:1060-70.
Chan HF, Sun Y, Lin CH, Chen RC. Madelung's disease associated with polyneuropathy and symptomatic hypokalemia. J Formos Med Assoc 2013 May;112:283-6.
Sun Y, Chang YH, Chen HF, Su YH, Su HF, Li CY. Risk of Parkinson Disease Onset in Patients With Diabetes: A 9-year population-based cohort study with age and sex stratifications. Diabetes Care 2012 May;35:1047-9.
Lin YL, Chen SY, Lai LC, Chen JH, Yang SY, Huang YL, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen WJ, Chen YC. Genetic polymorphisms of clusterin gene are associated with a decreased risk of Alzheimer's disease. Eur J Epidemiol. 2012.
Hong CT, Sun Y*, Lu CJ, Shin HC, Chen RC. Prediction of infarct growth and neurologic deterioration in patients with positive perfusion-diffusion mismatch. Clin Neurol Neurosurg 2012 May;114:376-80.
Cheng HC, Sun Y, Lai LC, Chen SY, Lee WC, Chen JH, Chen TF, Chen HH, Wen LL, Yip PK, Chu YM, Chen WJ, Chen YC. Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease. Journal of negative results in biomedicine. 2012;11:5.
Chen YC, Yip PK, Huang YL, Sun Y, Wen LL, Chu YM, Chen TF. Sequence variants of toll like receptor 4 and late-onset Alzheimer's disease. PLoS One. 2012;7(12):e50771.
Chen SY, Chen TF, Lai LC, Chen JH, Sun Y, Wen LL, Yip PK, Chu YM, Chen YC. Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease. J Neuroinflammation 2012;9:21.
Lin KP, Chen SY, Lai LC, Huang YL, Chen JH, Chen TF, Sun Y, Wen LL, Yip PK, Chu YM, Chen WJ, Chen YC. Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease. PLoS One 2011;6:e20573.
Sun Y, Lu CJ, Chen RC, Chien KL. Lack of association between total serum homocysteine and extracranial cerebral flow. J Formos Med Assoc 2010 Apr;109:278-86.
Lu CJ, Sun Y*, Chen SS. Incidence of Creutzfeldt-Jakob disease in Taiwan: a prospective 10-year surveillance. Eur J Epidemiol 2010 May;25:341-7.
Sun Y, Lu CJ, Lin CH, Wen LL. Interleukin-1beta is increased in the cerebrospinal fluid of patients with small infarcts. Eur J Neurol 2009 Jul;16:858-63.
Sun Y, Chien KL, Hsu HC, Su TC, Chen MF, Lee YT. Use of serum homocysteine to predict stroke, coronary heart disease and death in ethnic Chinese. 12-year prospective cohort study. Circ J 2009 Aug;73:1423-30.
Sun Y, Lai MS, Lu CJ, Chen RC. How long can patients with mild or moderate Alzheimer's dementia maintain both the cognition and the therapy of cholinesterase inhibitors: a national population-based study. Eur J Neurol 2008 Mar;15:278-83.
Hong CT, Sun Y, Lu CJ. Fatal intoxication using amantadine and pramipexole in a uremic patient. Acta Neurol Taiwan 2008 Jun;17:109-11.
Sun Y, Lu CJ, Chien KL, Chen ST, Chen RC. Efficacy of multivitamin supplementation containing vitamins B6 and B12 and folic acid as adjunctive treatment with a cholinesterase inhibitor in Alzheimer's disease: a 26-week, randomized, double-blind, placebo-controlled study in Taiwanese patients. Clin Ther 2007 Oct;29:2204-14.
Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan 2005 Jun;14:48-54.
Lu CJ, Kao HL, Sun Y, Liu HM, Jeng JS, Yip PK, Lee YT. The hemodynamic effects of internal carotid artery stenting: a study with color-coded duplex sonography. Cerebrovasc Dis 2003;15:264-9.
Lu CJ, Kao HL, Sun Y, Liu HM, Jeng JS, Yip PK. Postprocedural complications after angioplasty with stenting of the internal carotid artery. Cerebrovasc Dis 2003;16:308-10.
Sun Y, Lin CH, Lu CJ, Yip PK, Chen RC. Carotid atherosclerosis, intima media thickness and risk factors--an analysis of 1781 asymptomatic subjects in Taiwan. Atherosclerosis 2002 Sep;164:89-94.
Lu CJ, Sun Y, Jeng JS, Huang KM, Hwang BS, Lin WH, Chen RC, Yip PK. Imaging in the diagnosis and follow-up evaluation of vertebral artery dissection. J Ultrasound Med 2000 Apr;19:263-70.
Lu CJ, Sun Y, Huang KM. Leptomeningeal enhancement after carotid stenting. Stroke 2000 Sep;31:2274-5; author reply 6-7.
Sun Y, Yip PK, Jeng JS, Hwang BS, Lin WH. Ultrasonographic study and long-term follow-up of Takayasu's arteritis. Stroke 1996 Dec;27:2178-82.
Sun Y, Cheng AL, Chen CL, Huang KM, Wong JM, Chen RC. An early gastric cancer presented with widespread metastasis, disseminated intravascular coagulation, and a fulminant clinical course – to the memory of Dr. Ming-Yau Chung. Acta Neurol Sin 1995;4:183-90.
二、特殊醫療著作
Homocysteine and vascular diseases (博士論文) 2009.