陳世彬醫師詳細介紹

國立陽明大學醫學系

國立陽明大學臨床醫學研究所博士

哈佛醫學院麻州總醫院中風及神經血管調節研究室進行博士後研究

-迄今臺北榮民總醫院醫學研究部轉譯研究科主治醫師兼科主任

-迄今臺北榮民總醫院神經內科主治醫師

-迄今國立陽明交通大學臨床醫學研究所所長

-迄今國立陽明交通大學臨床醫學研究所教授

-迄今國立陽明交通大學腦科學研究所合聘教授

-迄今國立陽明交通大學神經科學研究所合聘教授

-迄今中研院跨領域神經科學-國際研究生博士班學程 (TIGP-INS)教授

-迄今The Journal of Headache and Pain 副主編(Associate Editor)

-迄今國際頭痛學會科學與研究委員會委員

-迄今臺北榮民總醫院細胞治療核心實驗室主持人

-迄今臺北榮民總醫院細胞治療小組執行秘書

-亞洲區域頭痛聯盟秘書長 (Secretary General, Asian Regional Consortium of Headache)

-國際頭痛學會官方期刊Cephalalgia副主編(Associate Editor, Cephalalgia)

-國際頭痛學會官方期刊子期刊Cephalalgia Reports副主編(Associate Editor, Cephalalgia Reports)

-臺北榮民總醫院醫學科技大樓管理中心主任

-臺北榮民總醫院教師培育研究技巧課程規畫小組主席

-桃園榮民醫院急診及神經內科主治醫師

-台灣頭痛學會秘書長

頭痛 帕金森氏症 失智症 神經免疫疾病

頭痛

帕金森氏症

失智症

神經免疫疾病

三叉神經痛

台灣醫師執照 台灣神經科專科執照

雷擊頭痛及可逆性腦血管收縮症候群之臨床、影像及分子生物學研究 RCVS是最嚴重最危險的複雜性神經血管疾病之一，其主要臨床表現為反覆發作如爆炸般的頭痛(雷擊頭痛)合併血管收縮，這些劇烈頭痛讓病患嚴重失能、反覆至急診就診、甚至因此害怕從事這些日常生活活動，影響生活甚鉅，且病患有相當風險產生缺血性中風、腦出血或腦後方白質病變等併發症。針對RCVS，我們從釐清其臨床表現與病程、建立檢查與治療標準流程準則、找出其預測併發症的準則及長期預後、 開發新影像技術協助診治乃至病生理機轉的探討，已發表系列論文於國際知名期刊如JAMA Neurology, Annals of Neurology, Neurology, Cephalalgia等,研究成果質與量居國際領先地位。目前團隊正致力於開發新的影像診斷工具及深入探討其病生理機轉。

偏頭痛病生理機轉之生物標記、動物模式、腦連結體及基因體學研究。 偏頭痛是造成最多疾病負擔的神經科疾病，造成的失能人年數在世界所有慢性疾病裡排名第二，對社會經濟與醫療體系造成巨大的衝擊，但其病生理機轉尚未釐清，治療選擇亦有限。團隊目前主要成果為建立偏頭痛動物模式探討偏頭痛的病生理機轉,促進瞭解偏頭痛新的病生理機轉及開發新的治療標的成果發表於Brain, Pain, JCBFM等雜誌。亦發表了台灣第一個也是亞洲唯一一個偏頭痛全基因體關聯性研究，找到台灣人偏頭痛特有的基因，提供未來病生理機轉研究重要方向。目前正持續透過臨床或基礎的研究，開發新的頭痛動物模式及深入探討偏頭痛基因體與腦連結體間的交互影響，希望未來可提供疾病新診斷或治療之契機，進而減輕病患及醫療體系負擔。

Chen SP, Fuh JL, Lirng JF, Chang FC, Wang SJ.* Recurrent primary thunderclap headache and benign CNS angiopathy: spectra of the same disorder? Neurology. 2006;67:2164-9

Chen SP,Fuh JL, Chang FC, Lirng JF, Shia BC, Wang SJ.* A transcranial color doppler study for reversible cerebral vasoconstriction syndromes. Annals of Neurology 2008; 63: 751-7.

Chen SP,Fuh JL, Wang SJ,* Chang FC, Lirng JF, Fang YC, Shia BC, Wu JC. Magnetic resonance angiography in reversible cerebral vasoconstriction syndromes. Annals of Neurology 2010; 67: 648-56.

Chen SP, Chung YT, Liu TY, Wang YF, Fuh JL,* Wang SJ.* Oxidative stress and increased formation of vasoconstricting F2-isoprostanes in patients with reversible cerebral vasoconstriction syndrome. Free Radical Biology & Medicine. 2013;61C:243-248.

Chen SP, Fuh JL, Lirng JF, Wang YF, Wang SJ.* Recurrence of Reversible Cerebral Vasoconstriction Syndrome: a Long-Term Follow-up Study. Neurology2015; 84: 1-7

Chen SP,* Ay I, Lopes de Morais A, Qin T, Zheng Y, Sadeghian H, Oka F, Simon B, Eikermann-Haerter K, Ayata C. Vagus nerve stimulation inhibits cortical spreading depression. Pain2016; 157: 797-805

Chen SP¶, Fuh JL¶, Chung MY¶, Lin YC, Liao YC, Wang YF, Hsu CL, Yang YC, Lin MW, Chiou JJ, Wang PJ, Chen PK, Fan PC, Wu JY, Chen YT, Kao LS*, Fann CS*, Wang SJ*. Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan.Cephalalgia 2018; 38: 466-75

Chen SP, Qin T, Seidel JL, Zheng Y, Eikermann M, Ferrari MD, van den Maagdenberg AM., Moskowitz MA, Ayata C, Eikermann-Haerter K. Inhibition of the P2X7-pannexin 1 complex suppresses spreading depolarization and neuroinflammation. Brain2017; 140:1643-1656

Chen SP,* Chou KH,¶Fuh JL,¶ Huang YH, Huang CC, Lirng JF, Wang YF, Lin CP, Wang SJ.* Dynamic Changes in White Matter Hyperintensities in Reversible Cerebral Vasoconstriction Syndrome. JAMA Neurology 2018;75(9):1106-1113. (*Equal contribution; ¶Equal contribution)

Yalcin N¶, Chen SP¶, Yu ES, Liu TT, Yen JC, Atalay YB, Qin T, Celik F, van den Maagdenberg AM, Moskowitz MA, Ayata C, Eikermann-Haerter K*. Caffeine does not affect susceptibility to cortical spreading depolarization in mice. J Cereb Blood Flow Metab2019 Apr;39(4):740-750. (¶Equal contribution)

Cho SH¶, Ling YH¶, Lee MJ¶, Chen SP¶, Fuh L, Lirng JF, Cha JH, Wang YF, Wang SJ*, Chung CS*. Temporal profile of blood-brain barrier breakdown in reversible cerebral vasoconstriction syndrome. Stroke 2020 May;51(5):1451-1457. (¶Equal contribution; * Equal contribution

Wu CH, Lirng JF, Ling YH, Wang YF, Wu HM, Fuh JL, Lin PC, Wang SJ*, Chen SP*. Noninvasive characterization of human glymphatics and meningeal lymphatics in an in vivo model of blood-brain barrier leakage. Annals of Neurology 2021;89:111–124

Chen SP, Chang YA, Chou CH, Juan CC, Lee HC, Chen LK, Wu PC, Wang YF, Fuh JL, Lirng JF, Ducros A, Huang HD*, Wang SJ*. Circulating microRNAs associated with Reversible Cerebral Vasoconstriction Syndrome. Annals of Neurology 2021;89:459–473

Lee ZF, Huang TH, Chen SP*, Cheng IH*. Altered nociception in Alzheimer disease is associated with striatal-enriched protein tyrosine phosphatase signaling. Pain 2021 Jun 1;162(6):1669-1680. (*Equal contribution)

Ling YH, Wang YF, Lirng JF, Fuh JL, Wang SJ, Chen SP*. Post-reversible cerebral vasoconstriction syndrome headache. The Journal of Headache and Pain. 2021; 22(1): 1-8

Lin PT, Wang YF, Fuh JL, Lirng JF, Ling YH, Chen SP*, Wang SJ*. Diagnosis and Classification of Headache Associated with Sexual Activity Using a Composite Algorithm: a cohort study. Cephalalgia 2021 Dec;41(14):1447-1457 (*Equal contribution)

Tsao YC, Wang SJ, Hsu CL, Wang YF, Fuh JL, Chen SP*, Fann CSJ*. Genome-wide association study reveals susceptibility loci for self-reported headache in a large community-based Asian population Cephalalgia 2021 in press. (*Equal contribution)

Wu CH, Wu HM, Ling YH, Wang YF, Fuh JL, Lin CJ, Ling K, Lirng JF, Wang SJ*, Chen SP*. Blood brain barrier permeability in patients with reversible cerebral vasoconstriction syndrome assessed with dynamic contrast-enhanced MRI. Neurology 2021 Nov 2;97(18):e1847-e1859. (*Equal contribution)

Chen SP*, Wang SJ. Pathophysiology of reversible cerebral vasoconstriction syndrome. Journal of Biomedical Science. 2022; 29:72

Chen SP, Hsu CL, Wang YF, Yang FC, Chen TH, Huang JH, Pan LLH, Fuh JL, Chang HC, Lee YL, Chang HC, Lee KH, Chang YC, Fann CSJ, Wang SJ. Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan. The Journal of Headache and Pain 2022; 23:147. https://doi.org/10.1186/s10194-022-01517-6

Jiang YJ, Fann CSJ; Fuh JL, Chung MY, Huang HY, Chu KC, Wang YF, Hsu CL, Kao LS, Chen SP*, Wang SJ*. Genome-wide analysis identified novel susceptible genes of restless legs syndrome in migraineurs. The Journal of Headache and Pain. 2022 Mar 29;23(1):39 doi: 10.1186/s10194-022-01409-9. (*equal contribution).

Chou TM, Lee ZF, Wang SJ, Lien CC*, Chen SP*. CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine. The Journal of Headache and Pain. 2022 in press  (*equal contribution)

Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes- an under-recognised clinical emergency. Ther Adv Neurol Disord 2010; 3: 161-71.

Chen SP, Fuh JL, Wang SJ.* Reversible cerebral vasoconstriction syndromes: Current and future perspectives. Expert Rev Neurother 2011; 11:1265-76.

Chen SP, Ayata C.* Spreading Depression in Primary and Secondary Headache Disorders. Current Pain and Headache Reports. 2016; 20(7):44.

Chen SP, Tolner EA,* Eikermann-Haerter K.* Animal models of monogenic migraine. Cephalalgia 2016; 36: 704-21

Chen SP, Ayata C.* Novel Therapeutic Targets against Spreading Depression. Headache 2017;57:1340-1358.

Chou TM, Chen SP*. Animal Models of Chronic Migraine. Current Pain and Headache Reports. 2018: 19;22(6):44.

Harriott AM, Takizawa T, Chung DY, Chen SP*. Spreading Depression as a Model of Migraine. The Journal of Headache and Pain 2019;20(1):45.

Tolner E. *, Chen SP, Eikermann-Haerter K. Current understanding of cortical structure and function in headache. Cephalalgia 2019; 39(13):1683-1699

Chen SP, Eikermann-Haerter K.* How imaging can help us better understand the migraine-stroke connection. Headache 2020 Jan;60(1):217-228.

Chen SP, Pascual J, Wang SJ. Chapter 25: Exertional and Sex Headache– In Michel Ferrari, Joost Haan, Andrew Charles, David Dodick, and Fumihiko Sakai (eds.), Oxford Textbook of Headache Syndromes (Oxford Textbooks in Clinical Neurology), Oxford Press, 2016

Chen SP, Wang SJ. Chapter 15. Reversible cerebral vasoconstriction syndrome. International Neurology. 2nd 2016; DOI: 10.1002/9781118777329.ch15 (Publisher: Wiley-Blackwell)

Chen SP, Theriot J, Brennan KC, Ayata C. Chapter 19. Animal model of migraine aura. Neurobiologic Basis of Migraine. 1st Edited by Turgay Dalkara and Michael A. Moskowitz. JohnWiley & Sons, Inc. 2017

Chen SP, Wang SJ. Headaches due to vascular disorders. Modern Day Management of Headache- Questions and Answers. Edited by K Ravishankar, Randolph W Evans and Shuu-Jiun Wang. Jaypee- The Health Science Publisher, 2017

Takizawa T, Ayata C, Chen SP*. Therapeutic implications of cortical spreading depression models in migraine in Progress in Brain Research. Edited by Lau and Shuu-Jiun Wang. 2020 Elsevier B.V.