季康揚醫師詳細介紹

國立陽明大學醫學院醫學士

美國密蘇里大學生理學博士

2022-迄今台灣神經罕見疾病學會秘書長

2021-迄今國立陽明交通大學生理學研究所兼任助理教授

2020-迄今臺北榮民總醫院神經內科主治醫師

2022-迄今國立陽明交通大學醫學系導師

2019-2020臺北榮民總醫院神經內科總醫師

2016-2019臺北榮民總醫院神經內科住院醫師

2015-2016臺北榮民總醫院不分科住院醫師

2010-2011美國密蘇里大學生理學實驗助教

周邊神經肌肉疾病

神經基因學之分子診斷

神經科專科醫師（神專1317號）

Tsai MF, Jih KY, Shimizu H, Li M, Hwang TC. Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels. J Biol Chem. 2010;285(48):37663-37671.

Jih KY, Li M, Hwang TC, Bompadre SG. The most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR. J Physiol. 2011;589(Pt 11):2719-2731.

Jih KY, Hwang TC. Nonequilibrium gating of CFTR on an equilibrium theme. Physiology (Bethesda). 2012;27(6):351-361.

Jih KY, Sohma Y, Hwang TC. Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation. J Gen Physiol. 2012;140(4):347-359.

Jih KY, Sohma Y, Li M, Hwang TC. Identification of a novel post-hydrolytic state in CFTR gating. J Gen Physiol. 2012;139(5):359-370.

Jih KY, Hwang TC. Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle. Proc Natl Acad Sci U S A. 2013;110(11):4404-4409.

Lin WY, Jih KY, Hwang TC. A single amino acid substitution in CFTR converts ATP to an inhibitory ligand. J Gen Physiol. 2014;144(4):311-320.

Jih KY, Lin WY, Sohma Y, Hwang TC. CFTR potentiators: from bench to bedside. Curr Opin Pharmacol. 2017;34:98-104.

Jih KY, Chung CP, Chang YY, et al. Mutational analysis of CCM1, CCM2 and CCM3 in a Han Chinese cohort with multiple cerebral cavernous malformations in Taiwan. Clin Genet. 2018;94(3-4):389-390.

Tsai PC, Liao YC, Jih KY, Soong BW, Lin KP, Lee YC. Genetic analysis of ANXA11 variants in a Han Chinese cohort with amyotrophic lateral sclerosis in Taiwan. Neurobiol Aging. 2018;72:188 e181-188 e182.

Chou CT, Soong BW, Lin KP, Tsai YS, Jih KY, Liao YC, et al. Clinical characteristics of Taiwanese patients with Hereditary spastic paraplegia type 5. Ann Clin Transl Neurol. 2020;7(4):486-96.

Jih KY, Lin KP, Tsai PC, Soong BW, Liao YC, Lee YC. Investigating TBP CAG/CAA trinucleotide repeat expansions in a Taiwanese cohort with ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2020:1-6.

Jih KY, Tsai PC, Tsai YS, Liao YC, Lee YC. Rapid progressive ALS in a patient with a DNAJC7 loss-of-function mutation. Neurol Genet. 2020;6(5):e503.

Tsai YS, Lin KP, Jih KY, Tsai PC, Liao YC, Lee YC. Hand-onset weakness is a common feature of ALS patients with a NEK1 loss-of-function variant. Ann Clin Transl Neurol. 2020;7(6):965-71.

Jih KY, Chou YT, Tsai PC, et al. Analysis of NOTCH2NLC GGC repeat expansion in Taiwanese patients with amyotrophic lateral sclerosis. Neurobiol Aging 2021;108:210-12.

Liao YC, Chang FP, Huang HW, Chen TB, Chou YT, Hsu SL, Jih KY, Liu YH et al. GGC Repeat Expansion of NOTCH2NLC in Taiwanese Patients With Inherited Neuropathies. Neurology 98.2 (2022): e199-e206.

Tsai PC, Jih KY, Shen TY, et al. Genetic and Functional Analysis of Glycosyltransferase 8 Domain-Containing Protein 1 in Taiwanese Patients With Amyotrophic Lateral Sclerosis. Neurol Genet 2021;7(6):e627.

Hsu SL, Jih KY, Lin KP, et al. Assessing the NOTCH2NLC GGC repeat expansion in Taiwanese patients with hereditary spastic paraplegia. Parkinsonism Relat Disord 2022;96:43-44.